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Duromine phentermine 30mg

Duromine phentermine 30mg is used to reduce body weight in obese or overweight patients. Phentermine is combined with a resin which slowly releases the phentermine so the effect of Duromine lasts all day.

PHARMACEUTICAL FORM

Modified-release capsule.

• 15mg capsule – grey and green, marked Duromine 15 on cap and body
• 30mg capsule – grey and reddish brown, marked Duromine 30 on cap and body
• 40mg capsule – grey and orange, marked Duromine 40 on cap and body

CLINICAL PARTICULARS

THERAPEUTIC INDICATIONS

Duromine is an anorectic agent indicated in the management of obesity as a short-term adjunct
in a medically monitored comprehensive regimen of weight reduction based, for example, on exercise, diet (caloric/kilojoule restriction) and behaviour modification in obese patients with a body mass index (BMI) of 30 kg/m2 or greater. The treatment with Duromine can be initiated in overweight patients with a lower BMI (25 to 29.9 kg/m2), which increases the risk of morbidity from a number of disorders. Secondary organic causes of obesity should be excluded by diagnosis before prescribing this agent.

DOSE AND METHOD OF ADMINISTRATION

Adults and adolescents over 12 years:

One capsule daily at breakfast, swallowed whole. Evening dosing should be avoided, as this agent
may induce insomnia. It is recommended that treatment should be initiated under the care of physicians experienced in the treatment of obesity.

The recommended starting dose is 30mg daily. Larger framed individuals may require 40mg
daily. The recommended maintenance dose, either continuous or intermittent is 15 to 40 mg daily depending on responsiveness. The recommended dose of Duromine should not be exceeded to increase the effect. Duromine should not be combined with other appetite suppressants. Patients require medical review after a defined course of treatment, which should not exceed three months.

Children under 12 years:

Duromine is not recommended for children under the age of 12 years as safety and efficacy have not been established.

PHARMACOLOGICAL PROPERTIES

PHARMACODYNAMIC PROPERTIES

Mechanism of action

Phentermine is a sympathomimetic amine with significant anorectic activity in animal models.
Its appetite suppressant effect is generally considered to be exerted through the hypothalamus,
but it is not certain that this is the only effect related to weight loss. Phentermine has major effects
on the dopaminergic and noradrenergic nervous systems. The cardiovascular effects include a
pressor response and increase in heart rate and force of contraction.

PHARMACOKINETIC PROPERTIES

Absorption

Absorption of Duromine phentermine 30mg is almost complete. The rate of absorption from the resin complex is significantly slower than that from the hydrochloride salt resulting in a lower and later peak blood level. Phentermine is readily absorbed from the gastro-intestinal tract.

Metabolism & Excretion

Following an oral dose of phentermine capsule, one study demonstrated urinary excretion of unchanged drug ranging from 62.7% to 84.8% in 72 hours. The remainder is metabolised in the liver. The half-life of phentermine is about 25 hours. In one study in volunteers acidification of the urine reduced the half-life to 7 – 8 hours.

PHARMACEUTICAL PARTICULARS

LIST OF EXCIPIENTS

Refer to Section 2 – Qualitative and quantitative composition.

INCOMPATIBILITIES

Incompatibilities were either not assessed or not identified as part of the registration of this
medicine.

SHELF LIFE

In Australia, information on the shelf life can be found on the public summary of the Australian
Register of Therapeutic Goods (ARTG). The expiry date can be found on the packaging.

 SPECIAL PRECAUTIONS FOR STORAGE Duromine phentermine 30mg

Store below 30⁰C

Side Effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while taking Duromine phentermine 30mg.

Duromine phentermine 30mg helps most people with a weight problem but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.